What is Mendelian Inheritance Principle? Mendel is known as the Father of Genetics. He worked on garden peas and gave Mendelian inheritance principles. According to the Mendelian inheritance Principle: Single gene controls a single character / one gene controls one character Inheritance is based on quality over quantity. Therefore, Mendelian inheritance is known as Qualitative […]
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Introduction Pedigree analysis is crucial for genetic studies. However, it is essential to learn what is pedigree analysis and how the trait is transferred from one generation to the next generation. Students often attempt to solve pedigrees analysis by merely observing them, but this is not the proper way to analyze pedigrees. It is always
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Autosomal Genetic Disorder: Edward Syndrome It is an autosomal genetic disorder caused due to the trisomy of 18th chromosome. This genetic abnormality disrupts normal development and leads to a variety of serious health issues, including intellectual disabilities and physical abnormalities. The syndrome was first described by geneticist John H. Edwards in 1960, after whom it
Definition of Genes and Alleles In this interactive lecture, we’ll explore the key differences between genes and alleles. So, let’s begin by asking: “Is an allele a gene?” It’s a common question and can be confusing for students due to the similarity of these terms. However, understanding the distinction is crucial for grasping Mendelian Genetics.
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Introduction to DNA Marker DNA marker as the name suggests is a sequence of DNA which is present at a specific site on DNA. In other words, DNA marker is that DNA sequence which has marked DNA and present in repetitive manner. For example, suppose there is a 15-20 nucleotide long sequence present on DNA
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Mechanism of Aneuploidy Nondisjunction (the inability of homologous chromosomes at meiosis or sister chromatids at mitosis to separate equally to opposite poles) in mitosis or meiosis is the main cause of most aneuploids. Disjunction is the term used for the normal separation of chromatids to opposite poles during nuclear division or karyokinesis. Nondisjunction is simply
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What is ELISA? ELISA stands for Enzyme Linked Immunosorbent Assay. It is a type of immunoassay used to identify either the antigen or antibody. This study antigens and antibodies — quantitative or qualitative analysis is done. Samples routinely used in ELISA include plasma, serum, cell lysates, tissue lysates, and cell culture, etc. What does quantitative
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What do you mean by Polymerase Chain Reaction? Polymerase chain reaction (PCR) is a molecular technique that is used to amplify specific segments of DNA for a wide range of molecular technology applications. This technique was developed by Kary Mullis and his coworkers in 1980s and received Nobel Prize for the same. PCR technique allows
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When a disease is present in a family, knowledge of defective gene transmission patterns can be used to compute the probability of prospective parents having a child with the disorder. Genetic counselor is the one who calculates genetic probability. Calculation of such genetic probability is important for prospective parents because they will be able to
There are four different kinds of inheritance in pedigree analysis. They are as follows: Tips to Solving Pedigree Problems: Autosomal Dominant Trait Example: Explanation: X-linked Dominant Trait: Example: Explanation: Autosomal Recessive Trait Explanation: X-linked Recessive Trait: Explanation: Let’s discuss a question: In the given pedigree, find out the nature of pedigree.
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